Effects of amount and intensity of physical training alone versus a combination diet and physical lifestyle intervention on health-related quality of life in the STRRIDE-PD randomized trial


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BMJ Open Diabetes Res Care. 2022 Jan;10(1):e002584. doi: 10.1136/bmjdrc-2021-002584.


INTRODUCTION: To determine the relative contributions of various amounts and intensities of exercise alone to a combined lifestyle intervention on measures of health-related quality of life (HrQoL).

RESEARCH DESIGN AND METHODS: Participants (n=162) were sedentary, overweight/obese, with prediabetes, and randomized to one of four 6-month interventions: (1) high amount/moderate intensity exercise -energy expenditure of 16 kcal/kg body weight/week (KKW) at 50% oxygen consumption (V̇O2) Reserve; (2) high/vigorous -16 KKW at 75% V̇O2 Reserve; (3) low/moderate -10 KKW at 50% V̇O2 Reserve; (4) low/moderate plus rpm -10 KKW at 50% V̇O2 reserve more of a low-calorie diet. The abbreviated 36-item survey (SF-36) and satisfaction with physical function and appearance (SPF/SPA) survey were assessed at baseline and after the intervention. Analyzes of covariance determined differences in change scores between groups (p

RESULTS: Throughout the intervention, all groups (p

CONCLUSIONS: In general, a low amount of moderate-intensity exercise combined with diet was the most effective intervention for improving HrQoL. Among exercise-only interventions, vigorous-intensity exercise provided the greatest impact on changes in physical function. On the other hand, low amounts of moderate-intensity exercise had the greatest impact on mental well-being, potentially being a more accessible dose of exercise for previously sedentary people with prediabetes.

PMID:35086944 | DOI: 10.1136/bmjdrc-2021-002584

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